Anti-Estrogens in Bodybuilding Pt.1 – Clomiphene – Doctor's Analysis of Side Effects & Properties

Physician’s analysis of Clomiphene as used in bodybuilding as an estrogen blocker and its side effects and properties. Clomiphene is primarily a female infertility drug, but bodybuilders use it for its anti-estrogen effects – as PCT, a replacement for TRT, and to combat anabolic steroid induced hypogonadism (ASIH.) Clomiphene in this use can have paradoxical effects, raising estrogen and possibly leading to gynecomastia, as well as various rare direct side effects. Importantly, it seems to have very negative mood effects in men who have used steroids, but not necessarily in men who have not. If you are considering taking clomiphene as an anti-estrogen or have taken it, please watch this video.

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– Classic SERM – selective estrogen receptor modulator
02:08 – Acts as an anti-estrogen in the hypothalamus
02:37 – Medical Uses
02:52 – In men: only works for secondary hypogonadism in the hypothalmus and pituitary, not primary in the testes
03:16 – Low T – used as “TRT” with a caveat: acts differently in men that have used steroids, often leads to poor mood
05:22 – Used as shortest duration SERM in PCT for two reasons
06:31 – Used to combat ASIH
08:28 – Vision issues
09:28 – Potential liver effects
11:07 – DVTs – deep vein thrombosis
12:19 – Potential gynecomastia and testicular tumors

Stay Strong and Healthy,
Dr. O


As the Anabolic Doc, since 2003, I’ve provided men who are using or have used anabolic steroids a confidential, ethical and professional medical venue to discuss their use. I do NOT in any way support the use of any performance enhancing drugs – PEDs, anabolic steroid or other medicine for muscle building or body transformation. The “off-label” use of PEDs, as such agents is considered elicit and may lead to adverse health outcomes. Please consult an expert health professional regarding any medical agent and do NOT use any medicine without the explicit advice and supervision of an appropriate medical expert.

This video is for education and information only. This is not medical advice. Only take medications as prescribed by your doctor. Do not take illegal substances. Taking steroids can lead to serious health consequences.

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